ISE and AD date & time Synchronization
If ISE node clock is not synchronized with the AD node clock, then authentication will fail.
Make sure that the date & time between ISE and AD node must be synchronized.
Step 1: You will be Unable to access ISE node through GUI?
Step 2: Make sure the date & time and time zone on ISE and AD must be synchronized.
Commands used:
show clock (To check the current date & time)
Step 3: Check date & time on the AD.
Step 4: If they are not in sync. You can manually sync the date and time on the ISE node via CLI.
Commands used:
Clock set Jan 17 04:58:00 2019
show clock (verify the date and time)
Step 5: Then go to browser and you will be able to access ISE.
Conclusion: ISE and AD node date & time should be in sync in order for GUI to work properly.